Modern remote sensing, geospatial information systems and hydraulic modeling technologies provide an opportunity to examine in detail the exposure of a given area to floods. Built up areas are the most vulnerable from land use categories in terms of human life and property value, so the protection of these areas is of key importance. The precise capabilities and use of the mentioned information and communication technologies in the field of exposure assessment of built up areas are studied through the case study of the Lower Don River. The amount of water flowing down the river is currently regulated by the Tsimlyansk Dam, which will reach the end of its design life span in the decade of 2020, thereby further increasing the significant flood risk in the downstream region. In this study, the effect of 4 possible flooding scenarios was modeled.